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Hrd definition2/13/2023 ![]() ![]() Recently, three independent DNA-based measures of genomic instability were developed on the basis of loss of heterozygosity (LOH), telomeric allelic imbalance (TAI), and large-scale state transitions (LST). Brigham and Women's Hospital, Boston, Massachusetts.īRCA1/2-mutated and some sporadic triple-negative breast cancers (TNBC) have DNA repair defects and are sensitive to DNA-damaging therapeutics. Dana-Farber Cancer Institute, Boston, Massachusetts. 11 Harvard Medical School, Boston, Massachusetts.
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